Guidelines developed to facilitate approaches to medical care, including the application of pharmacotherapy, provide evidence-based insights with graded recommendations on how to manage patients. Although based on the available evidence, the diversity of patients, limitations on clinical trials incorporated into the process, and development of guideline recommendations can create management decision challenges. They may not line up or match with other observations or experiences when utilized to create policy or directly apply these principles to patient care management decisions. Since guidelines are a key component in pharmacotherapy management, it is important to understand the development process, limitations of the recommendations, grading, and considerations for adapting to provide individualized, optimal patient care or application policy. This interactive session will explore how to understand the guideline development process, the critical assessment of these documents, and the ways to match and adapt them to craft optimal policy as well as allow individualized management decisions.